RevoDx Methicillin resistance qPCR Kit

Methicillin is antibiotic formerly used in the treatment of bacterial infections caused by organisms of the genus Staphylococcus. Methicillin is a semisynthetic derivative of penicillin. Methicillin resistance results from the production of an altered penicillin-binding protein known as PBP2a, which has decreased affinity for most β-lactam antibiotics. PBP2a is encoded by the gene mecA, which is carried on a mobile genetic element staphylococcal cassette chromosome type IV in CA-MRSA strains. Methicillin-resistant Staphylococcus aureus (MRSA) is a group of Gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus. MRSA is responsible for several difficult-to-treat infections in humans. It caused more than 100,000 deaths attributable to antimicrobial resistance in 2019.

Intended Use

RevoDx Methicillin resistance qPCR Kit is a real-time PCR test intended for the qualitative detection of mecA gene in single tube in which human RNase P is simultaneously detected.